How does the product work?
The product is a polymer-based implant which is situated under the skin of the ear. It contains a gonadotrophin-releasing hormone agonist (GnRH), which blocks signals from the brain to the ovary which prevents the ovulation process.
What is the duration of contraception?
After 2 years of laboratory studies indicate the initial laboratory formulations have the potential to provide contraception in female cattle for 12 months. The first Proof of Concept (POC) efficacy studies in live cattle are planned to begin Q1 2025. Data from these studies will guide the next phases of formulation development. Pendant Biosciences has the capability to design multiple variations of the polymer platform (porosity, drug load, release and rates of degradation). Shorter-acting, longer-acting or removable contraceptive implants will be developed in the future.
Can the product be removed from the ear during the payout period?
There is considerable interest in this use situation as a means of reversing the product’s contraceptive effect. Depending on the time since the product was administered, the implant may be able to be removed. However, this use situation has not been investigated.
How much will it cost?
Our pricing strategy aims to capture the benefits delivered by this unique technology whilst remaining competitive with existing contraceptive solutions.
How will the product be applied?
The product will be delivered as an implant under the skin of the ear. This delivery method is already widely used in the Australian beef industry. It is estimated that the vast majority of grainfed cattle in Australia and at least 20% of grassfed cattle in northern Australia destined for turn-off are treated with implants at some stage of their lives.
How will producers access the product?
Initial discussions with Australian Pesticides and Veterinary Medicines Authority (APVMA) indicate the product will be scheduled S4 (vet only) in Australia. It is envisaged that product will then be shipped directly to the customer (beef producer).
Will the product need cold chain storage?
It is likely the product will require storage between 4-8° C during storage,
shipment and before use.
Is the product biodegradable?
The current product is biodegradable
Does the technology work in males?
The current contraceptive product being investigated by Sorensis has no effect on male reproduction. Sorensis recognises the significant need for painless castration in males. This will become a research focus once funding is available. One of our advisors, Honorary Prof. Michael D’Occhio is a world authority on reproductivity biology in livestock.
Is this technology applicable to other species?
This technology applicable to other production and companion animal species. Sorensis aims to build a portfolio covering key unmet needs in both companion and production species.